Jeremy M. Simon, Ph.D. (he/him/his)
Associate Professor, Department of Genetics
Co-Principal, Bioinformatics and Analytics Research Collaborative (BARC)
Director, UNC Neuroscience Center Bioinformatics Core
Carolina Institute for Developmental Disabilities
University of North Carolina at Chapel Hill
Establishing and maintaining proper transcriptional programs is central to both development and disease, and involves the careful orchestration of transcription factors and chromatin modifier proteins. My groups seek to untangle these complex systems, ask biologically-driven questions, and formulate new hypotheses using analysis and integration of bulk or single-cell high-throughput sequencing approaches. I will focus on two vignettes: first, a longitudinal transcriptomics analysis of neocortical development in a mouse model of autism, and second, the identification of novel oncogenic drivers and mechanisms in renal cell carcinoma.