cBioPortal for Cancer Genomics is one of the most widely used platforms for visualizing and analyzing cancer genomics data. The platform is fully open source and actively maintained by KSG @ Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, Princess Margaret Cancer Centre, and The Hyve. KSG also maintains a local instance — cBioPortal @ DFCI — enabling researchers to explore all genomic data generated by the Profile project.
Key Capabilities
Visual summary of genomic alterations across a cohort of patients — mutations, copy number changes, and fusions in a single view.
Explore somatic mutations across genes and cancer types, with lollipop plots and protein domain annotations.
Kaplan-Meier survival curves stratified by genomic alterations, expression levels, or clinical attributes.
Compare mRNA expression across cancer types, patient cohorts, and genomic subgroups.
Query and compare data across hundreds of published cancer studies simultaneously.
Correlate genomic findings with clinical data including tumor type, treatment history, and outcomes.
Screenshots
OncoPrint — genomic alteration summary across a lung adenocarcinoma cohort
Mutation Mapper — EGFR somatic mutations mapped to protein domains
Study view — MSK-CHORD (24,950 patients, MSK-IMPACT). Click to enlarge.
Patient view — clinical timeline and genomic summary for an individual patient. Click to enlarge.
cBioPortal @ DFCI
In addition to the public platform, KSG maintains a local instance of cBioPortal at Dana-Farber. This private instance gives DFCI researchers secure access to genomic data from the Profile project — one of the most comprehensive clinical sequencing efforts in the US — enabling them to explore patient-level data and drive research discoveries directly from clinical sequencing results.